10 Natural Supplements to Support Fertility After 35

Expertly curated for women over 35 who are pursuing motherhood

Supporting Fertility with Natural Supplements

If you are here, chances are you have been thinking deeply about your fertility, thoughts of hope between ovulation strips and acupuncture appointments or doing your best to balance hope and heartbreak through each cycle. Fertile Optimism understands. Women just like you; radiant, thirty-five and beyond that are navigating hormonal shifts, seeking answers, and holding onto the dream of becoming a mother.

The truth is: fertility after thirty-five is not a closed door. It is a door that requires more thoughtful keys. And one of those keys is nourishing your body with targeted, evidence-supported nutrients that support egg quality, hormone balance, and womb wellness.

Below is a list of 10 natural supplements designed with you in mind. These are not just trendy options; they are backed by research and evidence-based results. When used wisely and with guidance, they can be a powerful part of your fertility-supporting routine.

A Gentle Reminder

Always consult with a licensed healthcare provider or fertility specialist before starting new supplements. Natural supplements, even those for fertility are most effective when paired with personalized guidance, lifestyle changes, and regular testing (like vitamin D levels, hormone panels, etc.). So, do not forsake seeking the advice of your licensed healthcare provider.

1. Coenzyme Q10 (Ubiquinol Form)

Why you need it: CoQ10 is like rocket fuel for your eggs. As we age, our mitochondria, the energy generators in our cells—slow down. CoQ10 revs them up, especially in the ovaries, improving egg quality and developmental potential.

• Ideal for: Women with diminished ovarian reserve or preparing for IVF
• Possible Option: Jarrow Formulas QH-Absorb Ubiquinol 200mg
• Evidence: Bentov & Casper, Fertility and Sterility, 2013 [1]  

2. Myo-Inositol + D-Chiro Inositol

Why you need it: These vitamin-like compounds regulate insulin and hormones, crucial for healthy ovulation. Particularly helpful for women with PCOS tendencies or irregular cycles.

• Ideal for: Cycle irregularity, high insulin, or unexplained infertility
• Possible Option: Ovasitol Inositol Powder by Theralogix
• Evidence: Unfer et al., Int J Endocrinol, 2017 [2]    

3. N-Acetyl Cysteine (NAC)

Why you need it: NAC boosts glutathione—your body’s primary antioxidant—and helps with egg detox, mucus quality, and overall reproductive resilience.

• Ideal for: PCOS, inflammation, poor cervical mucus
• Possible Option: NOW Supplements NAC 600mg
• Evidence: Oner & Muderris, EJOGRB, 2011[3]

4. Vitamin D3 (with K2 preferred)

Why you need it: Vitamin D plays a significant role in hormone regulation, follicular development, and immune support for implantation. A must-test nutrient.

• Ideal for: Women with low sun exposure or immune issues
• Possible Option: Sports Research Vitamin D3 + K2
• Evidence: Lerchbaum & Obermayer-Pietsch, Eur J Endocrinol, 2012 [4]

5. Omega-3 Fatty Acids (EPA/DHA)

Why you need it: Omega-3s lower inflammation, help hormone synthesis, and improve uterine lining. Omega-3 fatty acids also help balance prostaglandins which can improve implantation.

• Ideal for: Hormonal imbalances, inflammation, luteal phase support
• Possible Option: Nordic Naturals Prenatal DHA
• Evidence: Smuts et al., Am J Clin Nutr, 2005 [5]

6. Melatonin

Why you need it: This sleep aid does more than help you rest, it acts as an antioxidant within the follicles, supporting egg maturation and DNA protection.

• Ideal for: Poor egg quality, IVF prep, irregular sleep cycles
• Possible Option: Natrol Melatonin 3mg
• Evidence: Tamura et al., J Obstet Gynaecol Res, 2014 [6]

7. Royal Jelly

Why you need it: A bee originating superfood rich in amino acids, lipids, and nutrients that may help support estrogen levels and ovary function.

• Ideal for: Hormonal support, egg quality, pre-ovulatory phase
• Possible Option: Y.S. Eco Bee Farms Royal Jelly 1,000 mg
• Evidence: Mishima et al., J Ethnopharmacol, 2005 [7]

8. Vitex (Chaste Tree Berry)

Why you need it: This herb gently balances the menstrual cycle by encouraging progesterone production and regulating prolactin levels.

• Ideal for: Short luteal phase, PMS, post-birth control recovery
• Possible Option: Gaia Herbs Vitex Berry Liquid Phyto-Caps
• Evidence: Journal of Applied Pharmaceutical Science Vol. 12(03) [8]

9. L-Arginine

Why you need it: An amino acid that improves blood flow to the uterus and ovaries—essential for follicle nourishment and healthy endometrial lining.

• Ideal for: Thin lining, poor blood flow, older egg support
• Possible Option: NOW Sports L-Arginine 1000mg
• Evidence: Battaglia et al., Hum Reprod, 1999 [9]

10. Methylated B-Complex (with Methylfolate)

Why you need it: Unlike synthetic folic acid, methylfolate supports methylation; a process vital to egg DNA health, hormone production, and implantation.

• Ideal for: Women with MTHFR gene variants, preconception
• Possible Option: Pure Encapsulations B-Complex Plus
• Evidence: Supplementation with Folic Acid or 5-Methyltetrahydrofolate 2024 [10]

Evidence-Based References

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[1] Bentov, Y., & Casper, R. F. (2013). Fertility and Sterility, 99(1), 18–22.

[2] Unfer, V., et al. (2017). International Journal of Endocrinology, 2017.

[3] Oner, G., & Muderris, I. I. (2011). EJOGRB, 159(1), 127–131.

[4] Lerchbaum, E., & Obermayer-Pietsch, B. (2012). Eur J Endocrinol, 166(5), 765–778.

[5] Smuts, C. M., et al. (2003). The American Journal of Clinical Nutrition, 77(6), 1510–1516.

[6] Tamura, H., et al. (2012). J Obstet Gynaecol Res, 38(3), 161–166.

[7] Mishima, S., et al. (2005). J Ethnopharmacol, 101(1–3), 215–220.

[8] Van Die, M. D., et al. (2013). CNS Neurosci Ther, 19(6), 451–461.

[9] Battaglia, C., et al. (1999). Human Reproduction, 14(7), 1690–1694.

[10] Bailey, S. W., & Ayling, J. E. (2009). PNAS, 106(36), 15424–15429.